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KMID : 0545120200300050749
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Journal of Microbiology and Biotechnology
2020 Volume.30 No. 5 p.749 ~ p.752
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The Antimelanogenic Effect of Inularin Isolated from Flowers of Inula britannica on B16F10 Melanoma Cells and Zebrafish Embryos
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Jang Dae-Kil
Jung Seung-Hyun
Jeong Ji-Hye
Yoo Hee-Min
Lee Ik-Soo
Shin Han-Seung
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Abstract
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In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.
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KEYWORD
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Inula britannica, inularin, melanogenesis, B16F10 melanoma cells, zebrafish embryos
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